Bless your wife; as she bears about in her body the dying of the Lord Jesus that the LIFE of Jesus might be made manifest in her mortal flesh. Depression is very hard, but never forget it is He who is at work in her both to will and to do of His good pleasure.
Paul said if I am in my right mind it is a ministry for you, if I am out of my mind it is a ministry to God..... Although I do not know her path personally, I do see the Spirit of God filling up in her that which is behind of the sufferings of Christ, for it is our good pleasure to give our bodies to Him, which is our reasonable service.
By the grace of God we walk on water and are not consumed by it.